NISHIZONO Akira

FacultyNational University Corporation OITA UNIVERSITY
PositionDirector
 

Profile

Faculty

    National University Corporation OITA UNIVERSITY, School of Medicine/Department of MicrobiologyDirector

Name

    NISHIZONO Akira

Degree(1)

  • May 1985
  • 大分医科大学 医博課 第43号, Mar. 1989

Address

    1-1 Idaigaoka,Hasama-machi,Yufu,Oita 879-5593,Japan

Education

Classes

  • 2004
  • 2004
  • 2004
  • 2004
  • 2004
  • 2004
  • 2004
  • 2004
  • 2004
  • 2004
  • 2004
  • 2004
  • 2004
  • 2004
  • 2004
  • 2005
  • 2005
  • 2005
  • 2005
  • 2005
  • 2005
  • 2005
  • 2005
  • 2005
  • 2005
  • 2005
  • 2006
  • 2006
  • 2006
  • 2006
  • 2006
  • 2006
  • 2006
  • 2006
  • 2006
  • 2006
  • 2006
  • 2007
  • 2007
  • 2007
  • 2007
  • 2007
  • 2007
  • 2007
  • 2007
  • 2007
  • 2007
  • 2008
  • 2008
  • 2008
  • 2008
  • 2008
  • 2008
  • 2008
  • 2008
  • 2008
  • 2009
  • 2009
  • 2009
  • 2009
  • 2009
  • 2009
  • 2009
  • 2009

Research Achievements

Field of Study

    Microbiology (Bacteriology, Virology, Immunology)

Research Title

  • Emerging and Re-emerging Diseases, 1. Rabies virus: Molecular epidemiology, Construction of humanized antibodies (anti-rabies monoclonal antibodies) using combinatorial phage display system 2. Helicobacter pylori infection: Development of vaccine and analysis for pathogenesis for Helicobacter pylori infection 3. Antibody technology using phage display system for infectious diseases
  • Emerging and Re-emerging Diseases, 1.Rabie svirus: Molecular epidemiology, Construction of humanized antibodies (anti-rabies monoclonal antibodies) using combinatorial phage display system 2.Helicobacter pylori infection: Development of vaccine and analysis for pathogenesis for Helicobacter pylori infection 3.In vitro antibody production technology against infectious diseases
  • Emerging and Re-emerging Diseases, 1.Rabie svirus: Molecular epidemiology, Construction of humanized antibodies (anti-rabies monoclonal antibodies) using combinatorial phage display system 2.Helicobacter pylori infection: Development of vaccine and analysis for pathogenesis for Helicobacter pylori infection 3.In vitro antibody production technology against infectious diseases
  • Emerging and Re-emerging Diseases, 1. Rabies virus: Molecular epidemiology, Construction of humanized antibodies (anti-rabies monoclonal antibodies) using combinatorial phage display system 2. Helicobacter pylori infection: Development of vaccine and analysis for pathogenesis for Helicobacter pylori infection 3. Antibody technology using phage display system for infectious diseases
  • Emerging and Re-emerging Diseases, 1. Rabies virus: Molecular epidemiology, Construction of humanized antibodies (anti-rabies monoclonal antibodies) using combinatorial phage display system 2. Helicobacter pylori infection: Development of vaccine and analysis for pathogenesis for Helicobacter pylori infection 3. Antibody technology using phage display system for infectious diseases

Papers

  • 2004, Immune evasuin system of Helicobacter pylori, Helicobacter Research, 2004
  • 2004, Rabies, からだの科学増刊, 2004
  • 2004, New tumor necrosis factor-α-inducing protein released from Helicobacter pylori for gastric cancer progression, J.Cancer Research and Clinical Oncology, 2005
  • 2004, Transmission route of Helicobacter pylori in child, Helicobacter Research, 2004
  • 2004, Animal models for the study of Helicobacter-induced gastric carcinoma, J.Infect Chemother, 2004
  • 2004, SEROPREVALENCE OF IgG SPECIFIC FOR DENGUE VIRUS AMONG ADULTS AND CHILDREN IN SANTO DOMINGO, DOMINICAN EWPUBLIC, Am.J.Trop.Med.Hyg., 2004
  • 2004, CTLA-4 blockade inhibits induction of Helicobacter pylori-associated gastritis in mice, Clin Exp Immunol, 2004
  • 2005, Influence of age and duration of infection on bacterial load and immune responses to Helicobacter pylori infection in a murine model, Clinical and Experimental Immunology, 2005
  • 2005, A novel rapid fluorescent focus inhibition test for rabies virus using recombinant rabies virus visualizing a green fluorescent protein, Journal of Virological Methods, 2005
  • 2005, Construction of Human Fab Library and Isolation of Monoclonal Fabs with Rabies Virus-Neutralizing Ability, Microbiol. Immunol., 2005
  • 2005, New tumor necrosis factor--inducing protein released from Helicobacter pylori for gastric cancer progression, J. Cancer Res. Clin. Oncol, 2005
  • 2005, Efficacy of oncolytic reovirus against liver metastasis from pancreatic cancer in immunocompetent models, International Journal of Oncology, 2005
  • 2005, Genetic analysis of dog rabies viruses circulating in Bangkok, Infection Genetics and Evolution, 2005
  • 2005, Specific degradation of H. pylori urease by a catalytic antibody light chain, FEBS Journal, 2005
  • 2006, Transfer of Anitigen-Pulsed Dendritic Cells Induces Specific T-Cell Proliferation and a Therapeutic Effect against Long-Term Helicobacter pylori Infection in Mice, Infection and Immunity, 2006
  • 2006, Helicobacter pylori- associated oxidant monochloramine induces reactivation of Epstein-Barr virus(EBV)in gastric epithelial cells latently infected with EBV, Journal of Medical Microbiology, 2006
  • 2006, Genetic analysis of dog rabies viruses circulating in Bangkok., Infection Genetics and Evolition, 2006
  • 2006, Influence of Temperature on Growth of Legionella pneumophila Biofilm Determined by Precise Temperature Gradient Incubator, Journal of Bioscience and Bioengineering, 2006
  • 2006
  • 2006
  • 2006
  • 2007, Suppression of the Bacterial Antigen-Specific T Cell Response and the Dendritic Cell Migration to the Lymph Nodes by Osteopontin, Microbiol.Immunol, 2007
  • 2007, Effects of vaccination by a recombinant antigen ureB138(a segment of the -subunit of urease) against Helicobacter pylori infection, Journal of Medical Microbiology, 2007
  • 2007, Molecular Epidemiology of Rabies in Vietnam, Microbiol. Immunol., 2007
  • 2007, Construction of Human Fab(.1/.)Library and Identification of Human Monoclonal Fab Possessing Neutralizing Potency against Japanese Encephalitis Virus, Microbiol. Immunol., 2007
  • 2008, A simple and rapid immunochromatographic test kit for rabies diagnosis., Microbiol.Immunol, 2008
  • 2008, A pilot study on intradermal vaccination of Japanese rabies vaccine for pre-exposure immunization., Vaccine., 2008
  • 2008, Identification of a human monoclonal Fab with neutralizimg activity against H3N2 influenza A strain from a newly constructed human Fab library., Microbiol. Immunol., 2008
  • 2008, Catalytic features and eradication ability of antibody light chain UA15-L against H. pylori., J Biol Chem, 2008
  • 2008, Identification of the major antigenic protein of Helicobacter cinaedi and the immunogenicity during infections in human., Clin Vaccine Immunol, 2008
  • 2008, Diversity of human rotavirus G9 among children in Turkey., J Med Virol, 2008
  • 2008, Efficacy of oncolytic reovirus against human breast cancer cells., Oncol Rep, 2008
  • 2008, Therapeutic effects of molecularly designed antigen UREB138 for mice infected with Helicobacter pylori., Biotechnol Bioeng, 2008
  • 2008, TNF-alpha-inducing protein, a carcinogenic factor secreted from H.pylori enters gastric cancer cells., Int J Cancer, 2008
  • 2009, Development and evaluation of a rapid neutralizing antibody test for rabies., Journal of Virological Mwthods, 2009
  • 2009, Molecular characterization of a human grop C rotavirus detected first in Turkey., Vierus Genes, 2009
  • 2009, Reovirus inhibits the peritoneal dissemination of pancreatic cancer cells in a immunocompetent animal model, Oncology Reports, 2009
  • 2009, Rotavirus-associated intussusception followed by spontaneous resolution., Turk J Gastroenterol., 2009
  • 2009, Evaluation of a new tumor necrosis factor-α-inducing membrane protein of Helicobacter pylori as a prophylactic vaccine antigen, Helicobacter, 2009

Books

  • 2005, 医学書院, 2005
  • 2009, 南江堂, 2009
  • 2009, 医学書院, 2009

Industrial Property

  • 2004, antiviral drug
  • 2004, Human Fab library neutralizing rabies virus
  • 2005
  • 2006
  • 2007, antiviral drug
  • 2007, Human Fab library neutralizing rabies virus
  • 2008, antiviral drug
  • 2008, Human Fab library neutralizing rabies virus
  • 2009, 0. 2009

Learned Societies to Belong

  • American Society for Microbiology The Japanese Society for Virology (Board member) The Japanese Society for Bacteriology (Board member) The Molecular Biology Society of Japan The Japanese Association for Infectious Disease (Board member) The Japanese Society for Helicobacter Research (Board member) Society for General Microbiology, UK (Editorial Board member)

Grant-in-aid for Scientific Research

  • Research for novel therapeutic approach against pancreatic cancer using oncolytic reovirus, 2005.4.12006.3.31
  • 2007-2010
  • 205-2007
  • 2007-2010
  • 205-2007

Collaborative Research and Sponsored Research

  • 2005, 受託研究 「マウスを用いたin vivoでの抗体酵素の効果確認及びヒト型抗体酵素の作製」
  • 2006, 受託研究 「マウスを用いたin vivoでの抗体酵素の効果確認及びヒト型抗体酵素の作製」
  • 2006, 狂犬病ウイルス中和抗体の開発
  • 2007, 狂犬病ウイルス中和抗体の開発
  • 2007, 腸管感染症制御に有効な鳥類卵抗体の開発
  • 2007, LAMP法を用いた狂犬病ウイルス検出系の確立
  • 2008, 狂犬病ウイルス中和抗体の開発
  • 2008, 腸管感染症制御に有効な鳥類卵抗体の開発
  • 2008, LAMP法を用いた狂犬病ウイルス検出系の確立

Social Contribution

Social Activities

  • 2008

International Research Project

  • 2008


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